abstract：OBJECTIVE:Perlecan, which is also called heparan sulfate proteoglycan 2 (HSPG2), is a protein encoded by the HSPG2 gene that maps to 1p36.12 in the human genome. In this study, we assessed the independent prognostic value of HSPG2 in terms of overall survival (OS) and recurrence-free survival (RFS) in patients with LGG...

journal_title：European review for medical and pharmacological sciences

authors： Ma XL,Shang F,Ni W,Zhu J,Luo B,Zhang YQ

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Atrial fibrillation (AF) is the most common type of arrhythmia, especially in rheumatic heart disease (RHD) patients. The differences in structural remodeling and electrical remodeling between the left and right atrium associated with AF in RHD patients are well known, and alterations in the expression profil...

journal_title：European review for medical and pharmacological sciences

authors： Mei B,Liu H,Yang S,Liang MY,Yue Y,Huang SQ,Hou J,Chen GX,Wu ZK

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To optimize the management of patients with chronic hepatitis C virus (HCV). MATERIALS AND METHODS:We developed two questionnaires to determine Italian healthcare professionals' opinions on the overall management of HCV chronic liver disease and the use of direct-acting antivirals (DAAs) in the treatment of ...

journal_title：European review for medical and pharmacological sciences

authors： Di Marco V,Alberti A,Angarano G,Colombo M,Di Perri G,Gaeta GB,Ippolito G,Mangia A,Pasqualetti P,Craxì A

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:This study aims to investigate whether microRNA-373-3p could inhibit the progression of prostate cancer (PCa) by targeting and degrading AKT1. PATIENTS AND METHODS:Expression levels of microRNA-373-3p and AKT1 in PCa tissues and benign prostate hyperplasia (BPN) tissues were detected by quantitative Real-Tim...

journal_title：European review for medical and pharmacological sciences

authors： Qu HW,Jin Y,Cui ZL,Jin XB

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To investigate the regulatory effect of miR-328 on biological behaviors of hepatocellular carcinoma (HCC) cells, such as invasion and proliferation. PATIENTS AND METHODS:The expressions of miR-328 were detected in 48 pairs of HCC tissue samples and matched adjacent tissues, as well as in 3 kinds of HCC cell ...

journal_title：European review for medical and pharmacological sciences

authors： Liang F,Cui ZJ,Liu JD,Liu KP,Li L,Chen YL

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), as standing out for its distinguished sensitivity to all-trans retinoic acid and arsenic trioxide (ATO, As2O3). The As2O3-mediated degradation of PML-RARA (promyelocytic leukemia-retinoic acid receptor-α) oncoprotein via...

journal_title：European review for medical and pharmacological sciences

authors： Liu DM,Zhang XD,Yang L

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The occurrence rate of delayed fracture healing in diabetes mellitus patients is high. Transforming growth factor β1 (TGF-β1) is an important regulatory factor in bone tissue repair and regeneration. However, TGF-β1 expression and its function in diabetic patient fracture have not been fully elucidated. PATI...

journal_title：European review for medical and pharmacological sciences

authors： Wang WD,Cheng BZ,Kang WB,Zheng RW,Cai YL,Wang XJ

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To study the effects of chronic virus-mediated micro ribonucleic acid miR-27a on proliferation and migration capacities of liver cancer cells. PATIENTS AND METHODS:A total of 60 patients with primary liver cancer from January 2015 to December 2016 were selected as observation group, 60 patients with chronic ...

journal_title：European review for medical and pharmacological sciences

authors： Li W,Yu ZX,Ma BF

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To explore whether microRNA-138 could regulate the incidence and progression of laryngeal carcinoma through modulating proliferation and apoptosis of laryngeal carcinoma cells via MAPK6. PATIENTS AND METHODS:MicroRNA-138 expression in laryngeal carcinoma tissues and paracancerous tissues were detected by qRT...

journal_title：European review for medical and pharmacological sciences

authors： Zhou YH,Huang YY,Ma M

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To investigate the relations between the steatosis and liver functions, inflammations, and glucolipid metabolism in chronic hepatitis B patients. PATIENTS AND METHODS:A total of 144 chronic hepatitis B patients who were admitted to our hospital from January 2015 to April 2017 were selected and divided into t...

journal_title：European review for medical and pharmacological sciences

authors： Chen XL,Han YD,Wang H

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:By constructing the severe burns model in rat, we explored the effects of different doses of Ulinastatin (UTI) on protecting myocardium from oxidative stress and inflammatory reaction. MATERIALS AND METHODS:The severe burns model in rat was first constructed. Burned rats were intervened with different doses ...

journal_title：European review for medical and pharmacological sciences

authors： He F,Song Y,Ying WJ,Jin XY,Wang ZX,Su JD,Wang GY

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Bone loss is the main reason for postmenopausal osteoporosis, caused by estrogen deficiency. ERT (estrogen replacement therapy) has been demonstrated to protect bone loss efficiently. LncRNA (long non-coding RNA) has been proved to be important in different disease progression. We aimed at analyzing whether t...

journal_title：European review for medical and pharmacological sciences

authors： Li W,Zhu HM,Xu HD,Zhang B,Huang SM

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Hepatocarcinoma is a great threat to global health. MicroRNA-23a was suggested to regulate growth and apoptosis in certain cell lines. Our study was focused on growth, proliferation, and apoptosis of hepatocarcinoma cell line MHCC97H under the influence of microRNA-23a, and explored the mechanism of pro-apopt...

journal_title：European review for medical and pharmacological sciences

authors： Ji DG,Jiang CW,Luo X,Liu Z,Huang WJ,Zhang XH,Yu TH,Zhang LR

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:p38 MAPK are a class of protein kinase that may induce or prevent apoptosis in different circumstance. Emerging researches show that it plays a vital role in tumor progression and therefore understanding its dual role in different stages of lung cancer are important to investigate. Also in this study, we plan...

journal_title：European review for medical and pharmacological sciences

authors： Dong ZY,Zhou YR,Wang LX

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To evaluate pathological lesions in New Zealand white rabbits with acute kidney injury (AKI) of septic shock and to explore the potential role of poly (ADP-ribose) polymerase (PARP) in regulating AKI development. MATERIALS AND METHODS:Endotoxic shock model in New Zealand white rabbits was first constructed. ...

journal_title：European review for medical and pharmacological sciences

authors： Wang YM,Han RL,Song SG,Yuan XP,Ren XS

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To investigate the effectiveness of tranexamic acid (TA) application in two techniques: in the first one wound closure is performed before the tourniquet is released; in the second one, wound closure is performed after the tourniquet is released. PATIENTS AND METHODS:The study is conducted on four groups of ...

journal_title：European review for medical and pharmacological sciences

authors： Arslan A,Görmeli G

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:This study aimed at exploring and contrasting the clinical significances and values of MRI, CT and contrast-enhanced ultrasonography in FIGO staging of cervical carcinoma. PATIENTS AND METHODS:The contrast-enhanced ultrasonography, CT and MRI imaging data of 348 patients with cervical carcinoma confirmed by ...

journal_title：European review for medical and pharmacological sciences

authors： Yu L,Zhang HF,Jiang DW,Zhao DY,Liu H,Shen LM

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:MicroRNAs (miRNAs) are increasingly recognized as oncogenes or tumor suppressors in colorectal cancer (CRC). The aim of this study was to explore the expression and functions of miR-340-5p in CRC. PATIENTS AND METHODS:The expression of miR-340-5p in CRC tissues and cell lines was detected by quantitative RT-...

journal_title：European review for medical and pharmacological sciences

authors： Yang L,Men WL,Yan KM,Tie J,Nie YZ,Xiao HJ

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:This paper aims to evaluate the effects of right ventricular pressure load on left ventricular myocardial mechanics in patients with chronic obstructive pulmonary disease (COPD) by ultrasound speckle tracking imaging. PATIENTS AND METHODS:119 patients with COPD and pulmonary hypertension (PH) were selected f...

journal_title：European review for medical and pharmacological sciences

authors： Xia YJ,Sun HY,Jiang L,Liu B,Wang YY

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Ulcerative colitis (UC) is a kind of chronic inflammatory bowel diseases that seriously endangers human health. The pathogenesis of UC is closely related to the intestinal immune response. Cytokines exert a key role in the regulation of intestinal inflammatory and immune responses. Abnormalities in the functi...

journal_title：European review for medical and pharmacological sciences

authors： Wang ZL,Wang YD,Wang K,Li JA,Li L

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is one of the most common chronic joint diseases, caused by lesions in articular cartilage and synovial membranes. Synovitis is a major characteristic of OA, due to the proliferation of synoviocytes. Long noncoding RNAs (lncRNAs) have implicated to play an important role in many different ...

journal_title：European review for medical and pharmacological sciences

authors： Li X,Ren W,Xiao ZY,Wu LF,Wang H,Guo PY

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Increasing evidence indicates that dysregulation of miRNAs is involved in tumor progression and development. We aimed to determine potential values of miR-629 as a serum diagnostic and prognostic biomarker in pancreatic cancer (PC). PATIENTS AND METHODS:MiR-629 expression levels in PC tissues and serum were ...

journal_title：European review for medical and pharmacological sciences

authors： Shi W,Lu Y,Gong R,Sun JJ,Liu G

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of recombinant activated coagulation factor VII (rFVIIa) on apoptosis and the expressions of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) in rats with intracerebral hemorrhage (ICH). MATERIALS AND METHODS:A total of 90 8-week-old male Sprague-Dawley (SD) rats with...

journal_title：European review for medical and pharmacological sciences

authors： Ma YM,Zheng JX,Xu X,Shan YS,Gao ZW,Chen WG

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To explore the role of microRNA-326 in myocardial fibrosis after myocardial infarction (MI) and its underlying mechanism. MATERIALS AND METHODS:MI rat model was constructed via left anterior descending artery (LAD) ligation. Infarct tissues, infarct border zone tissues and remote zone tissues were harvested ...

journal_title：European review for medical and pharmacological sciences

authors： Wang CC,Shang BB,Yang CW,Liu YF,Li XD,Wang SY

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate whether miR-181d may be involved in steroid-induced osteonecrosis of the femoral head (ONFH) and its underlying mechanism. PATIENTS AND METHODS:Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used to detect the expression of miR-181d in bone marrow of 5 case...

journal_title：European review for medical and pharmacological sciences

authors： Xie Y,Hu JZ,Shi ZY

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the reversing effects of NOTCH1 inhibitor LY3039478 on cancer of the stomach's drug-resistance cells SGC7901/DDP and its relevant mechanism. MATERIALS AND METHODS:Drug-resistance cells SGC7901/DDP of human gastric cancer before and after reversal via NOTCH1 inhibitor LY3039478 were used as obj...

journal_title：European review for medical and pharmacological sciences

authors： Wang YL,Zhang Y,Huang XY,Zheng Y

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the potential function of miR-135a in glioma. PATIENTS AND METHODS:A total of 50 pairs of glioma tissue samples and para-carcinoma tissue samples were collected. Human glioma cell line (U251) and normal human astrocyte (NHA) were cultured. The expression of RNA and protein was detected by quan...

journal_title：European review for medical and pharmacological sciences

authors： Shi HZ,Wang DN,Xu F,Teng JH,Wang YL

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:This study aimed to investigate the correlation of serum calprotectin expression with risk and severity of psoriasis, as well as its predictive value for clinical response to tumor necrosis factor inhibitors (TNFi) treatment in psoriasis patients. PATIENTS AND METHODS:72 psoriasis patients and 70 health cont...

journal_title：European review for medical and pharmacological sciences

authors： Qian M,Song NJ

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Scurvy is defined as a deficiency of ascorbic acid, which is an essential exogenous vitamin in humans. Vitamin C is involved in collagen synthesis and its deficit can cause disorders of connective tissue. The most frequent symptoms are weakness, arthralgias, anorexia and depression, commonly associated with f...

journal_title：European review for medical and pharmacological sciences

authors： Antonelli M,Burzo ML,Pecorini G,Massi G,Landolfi R,Flex A

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers. PATIENTS AND METHODS:The expression level of miR-551b was determined ...

journal_title：European review for medical and pharmacological sciences

authors： Lukic A,Di Properzio M,Carico E,De Vitis C,Giglio S,Bordi G,Caserta D,Mancini R

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the role of phosphatidylinositol-3-kinase protein kinase B (PI3K/Akt) signaling pathway in the apoptosis of H1299 lung cancer cells induced by epigallocatechin gallate (EGCG). MATERIALS AND METHODS:H1299 lung cancer cells were treated with EGCG at a dose of 10 µM, 20 µM, and 40 µM, respectivel...

journal_title：European review for medical and pharmacological sciences

authors： Gu JJ,Qiao KS,Sun P,Chen P,Li Q

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of miR-124Aa on the proliferation, invasion and cytokine excretion of rheumatoid arthritis synovial fibroblasts (RASFs) in patients with rheumatoid arthritis (RA). PATIENTS AND METHODS:RASFs were separated for in-vitro culture, and transfected using lipidosome that connected with ch...

journal_title：European review for medical and pharmacological sciences

authors： Li J,Song Q,Shao L,Zhang LL,Guo XH,Mao YJ

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To explore whether Ipriflavone could prevent postmenopausal osteoporosis (PMOP) and improve bone quality via promoting osteogenesis of bone marrow-derived mesenchymal stem cell (MSCs). MATERIALS AND METHODS:MSCs were extracted from rats and identified using flow cytometry. Osteogenic specific genes and adipo...

journal_title：European review for medical and pharmacological sciences

authors： Gao AG,Zhou YC,Hu ZJ,Lu BB

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Osteoporotic vertebral compression fractures (OVCFs) are common diseases in elderly patients and can cause serious thoracolumbar compression fractures. For patients with such fractures, conservative treatment, nail-stick fixation, percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) can be sel...

journal_title：European review for medical and pharmacological sciences

authors： Hu KZ,Chen SC,Xu L

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:This study sought to compare the effects of proximal femoral nail anti-rotation (PFNA) and dynamic hip screw (DHS) helical blade treatments in patients with osteoporotic femoral intertrochanteric fractures. PATIENTS AND METHODS:Eighty elderly osteoporosis patients with femoral intertrochanteric fracture comp...

journal_title：European review for medical and pharmacological sciences

authors： Li H,Wang Q,Dai GG,Peng H

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the role of microRNAs (miRNAs) and its mechanism in osteoblast mineralization. MATERIALS AND METHODS:Real-time polymerase chain reaction (PCR), Northern Blot, and Western Blot were used to identify the expression mode of regulators. Overexpression and down-regulation experiments were carried o...

journal_title：European review for medical and pharmacological sciences

authors： Yang L,Huang LY,Li LB,Tang Z,Chen K,Chen LP,Luo HY,Luo J,Zhao XL

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To explore the use of magnetic resonance imaging (MRI) in the staging of rectal cancer and its relationship with p16 expression. PATIENTS AND METHODS:A total of 75 patients with rectal cancer treated in Oncology Department of our hospital from March 2013 to March 2017 were randomly included in this study. Th...

journal_title：European review for medical and pharmacological sciences

authors： Zheng N,Li YY,Cao YC,Liu S,Wang CH,Liu WJ

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Glioma is one common intracranial malignancy. Recently, there has been a large volume of published studies describing the functions of microRNAs as potential diagnostic markers for glioma. Data from several sources revealed that miR-378 played crucial roles in multiple tumors. However, much uncertainty still ...

journal_title：European review for medical and pharmacological sciences

authors： Shi HZ,Wang D,Sun XN,Sheng L

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Chronic Heart Failure (CHF) is associated with multi-hormonal derangement depicting a prevalence of catabolic vs. anabolic axes. Moreover, thyroid adaption is characterized by the reduced conversion of thyroxine to the active hormone triiodothyronine. On the other hand, hormones modulate synthesis and utiliza...

journal_title：European review for medical and pharmacological sciences

authors： Mancini A,Vergani E,Bruno C,Olivieri G,Di Segni C,Silvestrini A,Venuti A,Favuzzi A,Meucci E

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Lercanidipine is a calcium antagonist with no cardiodepressant activity, long lasting antihypertensive action and reno-protective effect. Our previous data demonstrated that lercanidipine blocks L-type calcium channels (CaL). However, no data are available concerning its effects on T-type calcium channels (Ca...

journal_title：European review for medical and pharmacological sciences

authors： Cerbai E,Mugelli A

更新日期：2018-06-01 00:00:00